Estriol

IUPAC Name: (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

Source: Occurs naturally in the placenta during pregnancy. It is used in hormone replacement therapy, menopause treatment for hot flashes, and is also used to help determine the health of unborn babies.

Summary: Estriol is a metabolite of estrone or estradiol. It is a 3-hydroxy steroid and a urinary estrogen, produced in high amounts in the placenta during pregnancy. It is also used in hormone replacement therapy, and to treat menopausal symptoms such as hot flashes. Estriol is also used to determine the health of unborn babies. It is part of the three major endogenous estrogens along with estradiol and estrone. It is soluble in water up to 27.34 mg/L and has a density of 1.27 g/mL at 25 C. A Koc value of 1,200 indicates low mobility within soil. Photolysis is expected to be a major method of natural degradation from soil and surface waters.

GHS Hazard Statement: H350, H351, H360, H362, H372, H400, H410, GHS08, GHS09